Neurotransmitter Analyzer
The ALEXYS Neurotransmitter Analyzer utilizes the extraordinary separation power of sub-2 μm packed columns. Plate numbers, retention times and detection sensitivity have been pushed to their limits. The system is based on a single channel configuration with kits for common neutronsmitters: noradrenaline, dopamine, serotonin and metabolites, GABA & glutamate or acetylcholine & choline etc. The system can be extended with several options and kits for any combination of neurotransmitters.
- UHPLC: Fast, High Performance
- Monoamines & metabolites, GABA/Glu, Acetylcholine/Choline
- Small Samples, Femtomole Detection Limits for MA's
- Customizable with Options and Kits
On-line Microdialysis
Applying an external electric valve instead of an autosampler makes the system suitable for sampling directly from the microdialysis flow. On-line microdialysis offers the unique possibility to obtain real time feedback on neurochemical changes. The extremely short run time in UHPLC facilitates a high temporal resolution.
System configuration
The Neurotransmitter Analyzer (pn 180.0091U) has several complementary kits for specific applications. Columns are all 1 mm ID and where possible the sub-2 μm packing is applied. All critical parts have an improved pressure rating, not only the LC 110S pump but also the autosampler, the pulsedampener and all connecting tubing and fittings. For GABA and Glutamate analysis an additional pump is applied to eliminate late eluting peaks with a step gradient.
The ALEXYS system comprises the following parts:
- AS 110 autosampler, cool, micro, UHPLC
- LC 110S HPLC pump
- OR 110 organiser rack, UHPLC
- Clarity data acquisition software
- DECADE II electrochemical detector, SCC
The column and cell are in the complementary kit.
Monoamines:
|
Part no |
Description |
|
180.0091U |
ALEXYS Neurotransmitter Analyzer |
|
180.0502 |
ALEXYS Monoamines SSC kit |
Acetylcholine and Choline:
|
Part no |
Description |
|
180.0091U |
ALEXYS Neurotransmitter Analyzer |
|
180.0506 |
ALEXYS Acetylcholine SCC kit |
GABA and Glutamate:
|
Part no |
Description |
|
180.0091U |
ALEXYS Neurotransmitter Analyzer |
|
180.0504 |
ALEXYS GABA/Glu SCC kit |
|
180.0602 |
LC step-gradient upgrade |
