Modulator Sepsolve INSIGHT
Sepsolve’s INSIGHT flow modulator overcomes the practical and performance difficulties experienced with other modulator designs - for example, the volatility restrictions associated with thermal modulators.
With cryogen-free operation and outstanding peak capacity, INSIGHT allows routine GC laboratories to benefit from the full power of GC×GC peak separation.
With Sepsolve’s INSIGHT any analyst is finally able to incorporate GC×GC into routine workflows, because of:
- Cryogen-free operation lowers running costs for routine GC×GC.
- Excellent repeatability for routine applications – rigid retention times and peak area RSDs are typically <5%.
- No volatility restrictions for confident analysis of VOCs (<C5) and SVOCs.
- Flexible configuration options, including GC×GC, heart-cut GC–GC, backflushing and parallel detection (e.g. TOF MS and FID).
- Retrofittable to all popular GCs.
- A compact design allows two INSIGHT devices to be configured in a single GC oven for enhanced productivity through dual-channel acquisition.
The next generation of flow modulators: INSIGHT, as a reverse fill/flush device, offers superior performance to first-generation forward fill/flush flow modulators. As well as its operational simplicity, minimal breakthrough allows sharp, symmetrical peaks, while an interchangeable collection channel provides greater flexibility in method development.
Delivering the confidence required for routine applications: The valve-based INSIGHT allows identical configurations to be installed across multiple instruments, unlike in thermal devices, where small variations in column position can have a large impact on results.
Tackling a wider range of samples: Flow modulation does not suffer from the same volatility restrictions as thermal modulation, because it does not rely on trapping analytes using a cold jet. Analytes as volatile as methane can be modulated efficiently without any need for liquid cryogen.
Reverse fill/flush operation: Differential flows in the INSIGHT modulator are used to ‘fill’ and ‘flush’ a sample loop – meaning low running costs for routine GC×GC and none of the logistical issues associated with liquid cryogen.
Improved peak capacity: Reverse fill/flush dynamics provide narrower peaks in the second dimension than previous generations of flow modulators, leading to improved sensitivity and greater peak capacity.
Flexible configuration: INSIGHT’s design makes it easy to configure for other (non-GC×GC) modes of operation – for example, connecting a second detector allows hassle-free heart-cutting.
Another level of information with parallel detection: Using parallel detection by MS and FID is the ideal way of achieving qualitative and quantitative analyses in a single run. While this can be troublesome to configure in thermally modulated systems, optimal alignment of retention times can easily be achieved with INSIGHT.
Keeping fragrance labs ahead of the regulations: Hundreds of similar terpenes, diverse sample types and complex matrices make monitoring allergens in cosmetics a challenging prospect. INSIGHT keeps labs ahead of the regulations, by providing the separation required for confident identification and quantitation of an extended suite of allergens.
Dual-channel configuration for enhanced productivity: The compact design of INSIGHT enables two devices to be installed within the same GC oven. This allows the simultaneous analysis of two samples using dual injection – optimising lab productivity.
Simple method development: INSIGHT can be retrofitted to most popular GCs, with the field kit containing everything you need to get started. An easy-to-use flow calculator is included to simplify method development, for beginners and experts alike.
